Material Safety Data Sheet
Polymyxin B sulfate

Section 1 - Chemical Product and Company Identification
MSDS Name: Polymyxin B sulfate
Catalog Numbers: 86-40302 

Section 2 - Composition, Information on Ingredients 
CAS#1405-20-5
Chemical Name: Polymyxin B sulfate
Percent  99%min
EINECS/ELINCS: 215-774-7
Hazard Symbols: Xn
Risk Phrases: 22

Section 3 - Hazards Identification 
EMERGENCY OVERVIEW
Harmful if swallowed. May cause irritation to eyes, respiratory system and skin.

Potential Health Effects
Eye:May cause eye irritation.
Skin: May be harmful if absorbed through skin. May cause skin irritation.
Ingestion: Harmful if swallowed
Inhalation: May be harmful if inhaled. May cause respiratory tract irritation.
Chronic: No information found.

Section 4 - First Aid Measures 
General advice: Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled: If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact: Wash off with soap and plenty of water. Consult a physician.
In case of eye contact: Flush eyes with water as a precaution.
If swallowed: Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

Most important symptoms and effects, both acute and delayed
Vomiting, Diarrhoea, Abdominal pain, To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.

Section 5 - Fire Fighting Measures 
General Information: Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self contained breathing apparatus for fire fighting if necessary.

Section 6 - Accidental Release Measures 
Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Avoid breathing dust.
Methods and materials for containment and cleaning up: Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.
Reference to other sections: For disposal see section 13

Section 7 - Handling and Storage 
Precautions for safe handling: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed.
Conditions for safe storage: Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
Recommended storage temperature: 2 - 8 °C

Section 8 - Exposure Controls, Personal Protection 
Engineering Controls: Use adequate ventilation to keep airborne concentrations low.

Personal Protective Equipment
Eye/face protection: Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin: Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
Body Protection: Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respirators: For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle respirator.For higher level protection use type OV/AG/P99 (US) or type ABEK-P2 (EU EN 143) respirator cartridges. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Section 9 - Physical and Chemical Properties 
Physical State: Crystalline powder

Color: White or almost white
Odor: Not available
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: N/A
Freezing/Melting Point: N/A
Autoignition Temperature: Not available
Flash Point: N.A
Decomposition Temperature:Not available.
Specific Gravity/Density: Not available.
Molecular Formula: C56H100N16O17S
Molecular Weight: 1301.56

Section 10 - Stability and Reactivity 
Chemical Stability: N/A
Conditions to Avoid: N/A
Incompatibilities with Other Materials: N/A
Hazardous Decomposition Products: N/A
Hazardous Polymerization: has not been reported.

Section 11 - Toxicological Information 
RTECS#: TR1150000
CAS#1405-20-5  
LD50/LC50: RTECS:
Carcinogenicity:
Polymyxin B sulfate,99%min- Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65.
WGK Germany :3
PackingGroup: III
Information on toxicological effects
Acute toxicity
LD50 Oral - mouse - 790 mg/kg
LD50 Intraperitoneal - mouse - 20,5 mg/kg
LD50 Intravenous - mouse - 5,4 mg/kg

Section 12 - Ecological Information 
Additional ecological information:
General notes: no data available

Section 13 - Disposal Considerations
Dispose of in a manner consistent  with federal, state, and local regulations.

Section 14 - Transport Information 
Shipping Name: No data available
UN proper shipping name
ADR/RID: Not dangerous goods
IMDG: Not dangerous goods
IATA: Not dangerous goods

Section 15 - Regulatory Information
European/International Regulations
      European Labeling in Accordance with EC Directives
           Hazard Symbols: Xn
           Risk Phrases:
                   R22:Harmful if swallowed
           Safety Phrases:
                  S22: Do not breathe dust
                  S24/25: Avoid contact with skin and eyes
          FLUKA BRAND F CODES
                  F3: Hygroscopic.
                  F8: Photosensitive.
                  F10: Keep under argon.

Section 16 - Additional Information
While the information herein is believed to be reliable, it is furnished without warranty of any kind. It shall be used only as a guide. We assume no liabilities from the use of this product or information contained herein.